P0302 - 2000 Expedition

2000 ford expedition 5.4L stared to have problems today, car would shake when accelarating, no power. went to A.Z. to get the codes p0302. cylinder 2 misfire. WHat do I need to do. Thanks

How many miles are on the truck? I would replace all the plugs if they havent been replaced and changwe the coil on number 2. If the plugs have been recently changed, replaced the plug and coil in number 2 cylinder. (second one back on passenger side)