I have a 1998 dodge dakaota 2wd, lowered 2" front and 4"in rear will 20's or 22's fit i wanna go big so Iam hoping 22's! if so what size tires on a 20 or 22 would be good thanks!

for 20's use 275/40/20 or 265/45/20
for 22's use 265/35/22

both 22's and 20's should fit.

whats gonna be the difference between 275/40/20 and the 265/45/20?

the 275's are wider and the overal diameter is closer to the stock one, however, only a couple of manufacturers make them and they're really expensive.

The 265/45 is a little taller than stock but a lot cheaper since its much more common and will also be more resistant to wheel damage from a pothole or something.