I recently replaced the CMFI on my 95 S-10 Blazer and now it won't start. Fuel pressure is 60 psi, (Ignition on), and spark to the plugs is good. Prior to replacing the CMFI the engine was running rough finally refusing to start after about a week. The old CMFI that was replaced was leaking significantly. My understanding of the CMFI is that it doesn't matter which poppet nozzle connects to each of the cylinders. Is this assumption correct? Any help in resolving this problem would be greatly appreciated.

Actually you have a CPI (central port injection) That said, did you properly connect leads back to the CPI unit? Did you disconnect the ignition module bolted to the coil? Is the coil firmly plugged in? Did you put the clip on the nut kit properly? I would pull the upper plenum again and check everything.

Tytian,
Your assumption is correct: all of the lines are connected to one central injector with a nozzle at each intake port. Hence the name: Central Multiport Fuel Injection. Each time the injector is energized, it sends fuel simultaneously to all nozzles.