(92 2.2 ltr) No spark in cylinders # 1 and 4. Replaced coil and wires, still no spark. Car was running great, stopped at light, had no power upon start up. any suggestions?

Might be the Ignition Module.

Check power lead(s) to 1+4 coil(s) for voltage.
Check crank sensor-it needs to see the #1 TDC position to start the module's firing sequence.

Check power lead(s) to 1+4 coil(s) for voltage.
Check crank sensor-it needs to see the #1 TDC position to start the module's firing sequence.

If the crank sensor doesn't see the #1 tdc , why does the other coil
# 2 and 3 still fire?

To test the coils power leads , are they the connectors to the left of the plug wire posts? and do I have to crank the engine while testing or just have the ignition on?

To test, you only need ignition on. Should be 12v.
Some coil setups, the module takes over after #1 fires-my 2.0-integrated module pack uses a waste spark distribution system like a Harley. It works this way.
If you have multiple coils-test each power lead to each coil.
Your module/coil setup may use a different type of system and sensor.
If you have a 4 cylinder with two separate coils-look for one bad coil for 1+4 or bad power lead to that coil.

[QUOTE=Three_Fingers]To test, you only need ignition on. Should be 12v.

Thanks I will give it a shot. I already tried a new coil, so I will test the ign. module .

Eh...Forgot to mention also...check the grounds (mounting plates, etc.) on that coil for any crap buildup that'd cause an open circuit or high resistance on that coil-preventing it from working right.
If you find any oil/gunk/etc. clean it off all nice and shiny/dry and put some conductive heat-sink grease on the metal grounding part.
It keeps the corrosion down and it can be bought at any Radio Shack or the car's dealer(conductive heat sink grease-such as used on HEI distributor ingnitor modules).